Crystal Structure and DNA Binding Properties of A Sulfide Bridged Dimeric Schiff Base Compound

In this research, a novel 4,4'-Diaminodiphenyl sulfide-based Schiff base compound [6,6'-((1E,1'E)-((thiobis (4,1-phenylene)) bis(azaneylylidene)) bis(methaneylylidene)) bis(3-(diethylamino) phenol) (A)], which is known to have good biological activity and forms the basis of anticancer drugs, was successfully synthesized. Structural characterization synthesized determined by FT-IR 1H-13C NMR, spectroscopies. Also, molecular structure single-crystal X-ray diffraction study. The DNA binding ability measured using UV-vis spectroscopy. Using spectral changes, constant calculated as Kb (M-1)= 6.25x105. value found suggests existence an intercalative interaction.